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dc.contributor.authorMorris, JKen_US
dc.contributor.authorSpringett, ALen_US
dc.contributor.authorGreenlees, Ren_US
dc.contributor.authorLoane, Men_US
dc.contributor.authorAddor, M-Cen_US
dc.contributor.authorArriola, Len_US
dc.contributor.authorBarisic, Ien_US
dc.contributor.authorBergman, JEHen_US
dc.contributor.authorCsaky-Szunyogh, Men_US
dc.contributor.authorDias, Cen_US
dc.contributor.authorDraper, ESen_US
dc.contributor.authorGarne, Een_US
dc.contributor.authorGatt, Men_US
dc.contributor.authorKhoshnood, Ben_US
dc.contributor.authorKlungsoyr, Ken_US
dc.contributor.authorLynch, Cen_US
dc.contributor.authorMcDonnell, Ren_US
dc.contributor.authorNelen, Ven_US
dc.contributor.authorNeville, AJen_US
dc.contributor.authorO'Mahony, Men_US
dc.contributor.authorPierini, Aen_US
dc.contributor.authorQueisser-Luft, Aen_US
dc.contributor.authorRandrianaivo, Hen_US
dc.contributor.authorRankin, Jen_US
dc.contributor.authorRissmann, Aen_US
dc.contributor.authorKurinczuk, Jen_US
dc.contributor.authorTucker, Den_US
dc.contributor.authorVerellen-Dumoulin, Cen_US
dc.contributor.authorWellesley, Den_US
dc.contributor.authorDolk, Hen_US
dc.description.abstractBACKGROUND: Surveillance of congenital anomalies is important to identify potential teratogens. METHODS: This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models. RESULTS: Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing. CONCLUSIONS: The annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4% (95% CI: 0.7% to 2.0%), 4.6% (1.0% to 8.2%), 3.4% (1.3% to 5.5%) and 4.1% (2.4% to 5.7%) respectively may reflect increases in maternal obesity and diabetes (known risk factors). The increased prevalence of cystic adenomatous malformation of the lung [6.5% (3.5% to 9.4%)] and decreased prevalence of limb reduction defects [-2.8% (-4.2% to -1.5%)] are unexplained. For renal dysplasia and maternal infections, increasing trends may be explained by increased screening, and deceases in patent ductus arteriosus at term and increases in craniosynostosis, by improved follow up period after birth and improved diagnosis. For oesophageal atresia, duodenal atresia/stenosis and ano-rectal atresia/stenosis recent changes in prevalence appeared incidental when compared with larger long term fluctuations. For microcephaly and congenital hydronephrosis trends could not be interpreted due to discrepancies in diagnostic criteria. The trends for club foot and syndactyly disappeared once registries with disparate results were excluded. No decrease in neural tube defects was detected, despite efforts at prevention through folic acid supplementation.en_US
dc.description.sponsorshipThis work was supported by the European Union in the framework of the Health Programme (2008-2013) to all authors. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.format.extente0194986 - ?en_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.subjectCongenital Abnormalitiesen_US
dc.subjectHistory, 20th Centuryen_US
dc.subjectHistory, 21st Centuryen_US
dc.subjectPopulation Surveillanceen_US
dc.titleTrends in congenital anomalies in Europe from 1980 to 2012.en_US
dc.rights.holder© 2018 Morris et al.
pubs.notesNo embargoen_US
pubs.publication-statusPublished onlineen_US

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