• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Trends in congenital anomalies in Europe from 1980 to 2012. 
    •   QMRO Home
    • Wolfson Institute of Preventive Medicine
    • Centre for Environmental and Preventive Medicine (CEPM)
    • Trends in congenital anomalies in Europe from 1980 to 2012.
    •   QMRO Home
    • Wolfson Institute of Preventive Medicine
    • Centre for Environmental and Preventive Medicine (CEPM)
    • Trends in congenital anomalies in Europe from 1980 to 2012.
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Trends in congenital anomalies in Europe from 1980 to 2012.

    Volume
    13
    Pagination
    e0194986 - ?
    DOI
    10.1371/journal.pone.0194986
    Journal
    PLoS One
    Issue
    4
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Surveillance of congenital anomalies is important to identify potential teratogens. METHODS: This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models. RESULTS: Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing. CONCLUSIONS: The annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4% (95% CI: 0.7% to 2.0%), 4.6% (1.0% to 8.2%), 3.4% (1.3% to 5.5%) and 4.1% (2.4% to 5.7%) respectively may reflect increases in maternal obesity and diabetes (known risk factors). The increased prevalence of cystic adenomatous malformation of the lung [6.5% (3.5% to 9.4%)] and decreased prevalence of limb reduction defects [-2.8% (-4.2% to -1.5%)] are unexplained. For renal dysplasia and maternal infections, increasing trends may be explained by increased screening, and deceases in patent ductus arteriosus at term and increases in craniosynostosis, by improved follow up period after birth and improved diagnosis. For oesophageal atresia, duodenal atresia/stenosis and ano-rectal atresia/stenosis recent changes in prevalence appeared incidental when compared with larger long term fluctuations. For microcephaly and congenital hydronephrosis trends could not be interpreted due to discrepancies in diagnostic criteria. The trends for club foot and syndactyly disappeared once registries with disparate results were excluded. No decrease in neural tube defects was detected, despite efforts at prevention through folic acid supplementation.
    Authors
    Morris, JK; Springett, AL; Greenlees, R; Loane, M; Addor, M-C; Arriola, L; Barisic, I; Bergman, JEH; Csaky-Szunyogh, M; Dias, C
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/36444
    Collections
    • Centre for Environmental and Preventive Medicine (CEPM) [305]
    Language
    eng
    Licence information
    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Copyright statements
    © 2018 Morris et al.
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.