RSS 1.0Centre for Environmental and Preventive Medicine (CEPM)
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The effect of dietary salt on blood pressure in individuals receiving chronic dialysis: a systematic review and meta-analysis of randomised controlled trials.
(Springer Nature, 2018-11-09)Dietary salt reduction in the general population lowers blood pressure and cardiovascular risk. Despite being widely recommended, there is limited evidence as to whether this is applicable to individuals with end-stage ... -
A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy.
(2019-02-14)BACKGROUND: E-cigarettes are commonly used in attempts to stop smoking, but evidence is limited regarding their effectiveness as compared with that of nicotine products approved as smoking-cessation treatments. METHODS: ... -
The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation.
(American Association of Immunologists, 2019-01-18)Genetic variants in C5orf30 have been associated with development of the autoimmune conditions primary biliary cirrhosis and rheumatoid arthritis. In rheumatoid arthritis, C5orf30 expression is cell-specific, with highest ... -
The illusion of polygenic disease risk prediction
(Springer Nature, 2019-01-12) -
The prodromes of Parkinson's disease.
(Wiley, 2018-11-17)Whilst the diagnosis of Parkinson’s disease (PD) relies on the motor triad of bradyki-nesia, rigidity and tremor, the underlying pathological process starts many years be-fore these signs are overt. In this prodromal phase ... -
When Guidelines Cause Hypertension.
(2018-12) -
Progressive nicotine patch dosing prior to quitting smoking: feasibility, safety and effects during the pre-quit and post-quit periods.
(2018-10-29)BACKGROUND AND AIMS: Nicotine replacement therapy (NRT) may be more effective in aiding smoking cessation if higher doses of nicotine from it can be tolerated. We examined the responses to, and 4-week abstinence rates ... -
Effects of product reformulation on sugar intake and health-a systematic review and meta-analysis.
(Oxford University Press on behalf of the International Life Sciences Institute, 2019-01-08)Context: Obesity, type 2 diabetes, and dental caries are all major public health problems in the United Kingdom and contribute substantially to healthcare costs. Objective: A systematic review and meta-analysis was conducted ... -
Identifying signals of potentially harmful medications in pregnancy: use of the double false discovery rate method to adjust for multiple testing.
(2019-02)AIMS: Surveillance of medication use in pregnancy is essential to identify associations between first trimester medications and congenital anomalies (CAs). Medications in the same Anatomical Therapeutic Chemical classes ... -
Scanning electron microscopy for blood micro-crystals in aortic stenosis patients.
(2018)BACKGROUND: Micro-crystals of calcium phosphate have been detected on the aortic valve of patients with aortic stenosis using scanning electron microscopy. It is not known whether crystalisation is specific to heart valve ... -
Serum sodium concentration and the progression of established chronic kidney disease.
(2018-10-16)BACKGROUND: Higher serum sodium concentration has been reported to be a risk factor for the development of incident chronic kidney disease (CKD), but its relationship with the progression of established CKD has not been ... -
Prenatal screening for Down syndrome in twin pregnancies: Estimates of screening performance based on 61 affected and 7302 unaffected twin pregnancies.
(2018-12)The aims of this study were to determine whether assumptions used in prenatal screening for Down syndrome in twin pregnancies are valid and derive estimates of risk and screening performance in twin pregnancies using ... -
Integration of child-parent screening and cascade testing for familial hypercholesterolaemia.
(2018-10-14)Objective To integrate child-parent screening and cascade testing into a single pathway-child-parent cascade screening (CPCS), for the identification of familial hypercholesterolaemia in the population and to estimate the ... -
The association between serum sodium concentration, hypertension and primary cardiovascular events: a retrospective cohort study.
(2019-01)The mechanisms underlying the adverse cardiovascular effects of increased salt intake are incompletely understood, but parallel increases in serum sodium concentration may be of importance. The aim of this retrospective ...
