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Sodium Reduction, miRNA Profiling and CVD Risk in Untreated Hypertensives: a Randomized, Double-Blind, Placebo-Controlled Trial.
(Springer Nature, 2018-08-24)Sodium reduction decreases blood pressure (BP) and cardiovascular mortality. However, the underlying molecular mechanisms are not well understood. We tested the hypothesis that reduction of sodium intake would change miRNA ... -
Rare single gene disorders: estimating baseline prevalence and outcomes worldwide
(Springer Nature Switzerland AG., 2018-08-14)© 2018, The Author(s). As child mortality rates overall are decreasing, non-communicable conditions, such as genetic disorders, constitute an increasing proportion of child mortality, morbidity and disability. To date, ... -
Mediators of the effect of nicotine pre-treatment on quitting smoking.
(Wiley Online, 2018-07-31)BACKGROUND AND AIMS: Using smoking cessation medications for several weeks prior to quitting smoking facilitates quitting success, but how it does so is not clear. Candidate theories are that pre-cessation medication ... -
Nicotine preloading for smoking cessation: the Preloading RCT.
(NIHR Journals Library, 2018-08)BACKGROUND: Nicotine preloading means using nicotine replacement therapy prior to a quit date while smoking normally. The aim is to reduce the drive to smoke, thereby reducing cravings for smoking after quit day, which are ... -
Prevalence of valproate syndrome in Europe from 2005 to 2014: A registry based multi-centre study.
(Elsevier, 2018-05-18)Women with epilepsy need to continue to take anticonvulsants during their pregnancies to prevent seizures from occurring. Since the 1980's, it has been known that the use of valproate (an anticonvulsant) in the first ...
