Browsing Centre for Endocrinology by Subject "FIPA"
Now showing items 1-12 of 12
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Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion.
(2019-04)Background: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionarily conserved and expressed widely throughout the organism. Loss-of-function AIP mutations predispose to young-onset pituitary adenomas. AIP ... -
Genetic Aspects of Pituitary Adenomas
(2017-06) -
Genetics of Acromegaly and Gigantism.
(MDPI, 2021-03-29)Growth hormone (GH)-secreting pituitary tumours represent the most genetically determined pituitary tumour type. This is true both for germline and somatic mutations. Germline mutations occur in several known genes (AIP, ... -
Genetics of Pituitary Tumours.
(Springer Nature Switzerland AG, 2019-10-07)Pituitary tumours are relatively common in the general population. Most often they occur sporadically, with somatic mutations accounting for a significant minority of somatotroph and corticotroph adenomas. Pituitary tumours ... -
Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland.
(2018-02-06)Despite the well-recognized role of loss-of-function mutations of the aryl hydrocarbon receptor interacting protein gene (AIP) predisposing to pituitary adenomas, the pituitary-specific function of this tumor suppressor ... -
Sporadic pituitary adenomas: the role of germline mutations and recommendations for genetic screening.
(2017-03)INTRODUCTION: Although most pituitary adenomas occur sporadically, these common tumors can present in a familial setting in approximately 5% of cases. Germline mutations in several genes with autosomal dominant (AIP, MEN1, ... -
Update on the Genetics of Pituitary Tumors
(2020-09)