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Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
(Nature Publishing Group, 2019-01-24)
Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR ...
B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis.
(Elsevier, 2019-02-22)
TLS develop in target organs of autoimmune diseases, transplantation and cancer.
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TLS can function as germinal centres supporting B-cell selection/differentiation.
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TLS can be destructive or have beneficial effects ...
Cathepsin L Induces Proangiogenic Changes in Human Omental Microvascular Endothelial Cells via Activation of the ERK1/2 Pathway
(Bentham Science Publishers, 2019)
Background: Metastasis still remains the major cause of therapeutic failure, poor prognosis and high mortality in epithelial ovarian cancer (EOC) patients. Previously, we showed that EOC cells secrete a range of factors ...
Plan S: In service or disservice to society?
(Oxford University Press, 2019-03-21)
The controversial plan for scientific research publications to be published in compliant Open Access Journals or on compliant Open Access Platforms is discussed. The article has been co-published with permission in European ...
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy
(MDPI AG, 2019-03-06)
Overexpression and secretion of the enzymes cathepsin D (CathD) and cathepsin L (CathL) is associated with metastasis in several human cancers. As a superfamily, extracellularly, these proteins may act within the tumor ...
Physical activity and left-ventricular trabeculation in the UK Biobank community-based cohort study
(BMJ Publishing Group, 2019-02-05)
Objective: Vigorous physical activity (PA) in highly trained athletes has been associated with heightened left ventricular (LV) trabeculation extent. It has therefore been hypothesised that LV trabeculation extent may ...
Automated quality control in image segmentation: application to the UK Biobank cardiovascular magnetic resonance imaging study
(BioMed Central, 2019-03-14)
Background: The trend towards large-scale studies including population imaging poses new challenges in terms
of quality control (QC). This is a particular issue when automatic processing tools such as image segmentation
methods ...
Soluble Guanylate Cyclase Stimulators and Activators.
(2019-01-29)
When Furchgott, Murad, and Ignarro were honored with the Nobel prize for the identification of nitric oxide (NO) in 1998, the therapeutic implications of this discovery could not be fully anticipated. This was due to the ...
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
(Bioscientifica, 2019-02-01)
While 95% of pituitary adenomas arise sporadically without a known inheritable predisposing mutation, in about 5% of the cases they can arise in a familial setting, either isolated (familial isolated pituitary adenoma or ...