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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
(Nature Research (part of Springer Nature), 2019-02-18)
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted ...
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
(Oxford University Press, 2019-01-29)
An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions ...
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
(American Heart Association, 2017-10-13)
Background—
Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ...
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
(Nature Research (part of Springer Nature), 2018-11-14)
Correction to: Nature Genetics https://doi.org/10.1038/s41588-018-0205-x, published online 17 September 2018.
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly ...
52 Genetic Loci Influencing Myocardial Mass
(2016-09-27)
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
(Nature Research (part of Springer Nature), 2019-03-29)
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a ...