Search
Now showing items 11-20 of 40
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
(Nature Research (part of Springer Nature), 2019-02-18)
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted ...
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
(Nature Research (part of Springer Nature), 2018-04-09)
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated ...
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
(American Heart Association, 2017-10-13)
Background—
Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ...
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
(Nature Research (part of Springer Nature), 2018-11-14)
Correction to: Nature Genetics https://doi.org/10.1038/s41588-018-0205-x, published online 17 September 2018.
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly ...
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
(Nature Research (part of Springer Nature), 2019-03-29)
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a ...
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
(Nature Research (part of Springer Nature), 2019-01-22)
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we ...