Browsing William Harvey Research Institute by Issue Date
Now showing items 21-40 of 4217
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Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome.
(1997-01-06)Interleukin-4 (IL-4) provides support for humoral immune responses through upregulation of T helper (Th) type 2 cell differentiation, but it is not known whether IL-4 promotes antibody-mediated autoimmune diseases such as ... -
Mechanism of gram-positive shock: identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure.
(1998-07-20)The incidence of septic shock caused by gram-positive bacteria has risen markedly in the last few years. It is largely unclear how gram-positive bacteria (which do not contain endotoxin) cause shock and multiple organ ... -
Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase: comparison to induction of iNOS.
(1999)This study compares the signal transduction pathway which leads to the upregulation of intercellular adhesion molecule-1 (ICAM-1) expression with that of the increase in the expression of inducible nitric oxide synthase ... -
High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia.
(1999-12-06)To assess the potency of low-affinity anti-red blood cell (RBC) autoantibodies in the induction of anemia, we generated an immunoglobulin (Ig)G2a class-switch variant of a 4C8 IgM anti-mouse RBC autoantibody, and compared ... -
Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.
(2000-04-17)Using three different Fcgamma receptor (FcgammaR)-deficient mouse strains, we examined the induction of autoimmune hemolytic anemia by each of the four immunoglobulin (Ig)G isotype-switch variants of a 4C8 IgM antierythrocyte ... -
Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 Isotypes of a high affinity anti-erythrocyte autoantibody
(Rockefeller University Press, 2002-03-18) -
Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population
(BMC, 2005-04-11)Background: Cocaine and amphetamine regulated transcript (CART) is an anorectic neuropeptide located principally in hypothalamus. CART has been shown to be involved in control of feeding behavior, but a direct relationship ... -
Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study
(Lippincott Williams & Wilkins, 2005-10-27)BACKGROUND AND PURPOSE: Previous work has shown that soluble heat shock protein 60 (HSP60; sHSP60), present in circulating blood, is associated with carotid atherosclerosis. In the current evaluation, we tested the hypothesis ...