Centre for Tumour Biology: Recent submissions
Now showing items 281-300 of 380
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Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations.
(2018-12)Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations ... -
Implications of Epigenetic Drift in Colorectal Neoplasia
(2019-02-01) -
In vivo bioassay to test the pathogenicity of missense human AIP variants.
(2018-08)BACKGROUND: Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose ... -
The evolutionary landscape of colorectal tumorigenesis
(2018-10)The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, ... -
Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma.
(2018-08-18)OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need. While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy ... -
A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.
(2018-08)The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. Prolonged HIF expression is ...