Centre for Tumour Biology: Recent submissions
Now showing items 181-200 of 380
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Modifying oncolytic viral therapy for pancreatic cancer
(2016-06-01) -
FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
(Macmillan Publishers, 2012-06)Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase/Akt pathway, and are key regulators of the cell cycle, apoptosis and response to oxidative stress. FOXOs have ... -
The ITGB6 gene: its role in experimental and clinical biology.
(2020-12)Integrin αvβ6 is a membrane-spanning heterodimeric glycoprotein involved in wound healing and the pathogenesis of diseases including fibrosis and cancer. Therefore, it is of great clinical interest for us to understand the ... -
Ca(2+)tapulting HSCs into action
(2018-08) -
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.
(Springer Verlag, 2013-01-23)BACKGROUND: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated ...