Browsing Centre for Tumour Biology by Subject "PHLDA1"

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    • PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer 

      Fearon, AE; Carter, EP; Clayton, NS; Wilkes, EH; Baker, A-M; Kapitonova, E; Bakhouche, BA; Tanner, Y; Wang, J; Gadaleta, E (Elsevier/Science Direct, 2018-02-27)
      Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ...