Browsing Centre for Tumour Biology by Subject "In situ hybridization"
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Chapter Eleven - Concurrent in situ analysis of point mutations and immune infiltrate in FFPE cancers
(Elsevier, 2020)Existing methodology for analysis of genetic heterogeneity generally involves digestion of the tumor tissue, followed by bulk DNA extraction or single cell preparation. Such methods destroy the tissue morphology, and ... -
In Situ Point Mutation Detection in FFPE Colorectal Cancers Using the BaseScope Assay.
(2020)In situ mutation detection (ISMD) is a powerful tool for the characterization of tumor heterogeneity at cellular resolution while preserving tissue morphology and spatial context. The BaseScope assay is a novel approach ...