Browsing Centre for Tumour Biology by Subject "Genomics"
Now showing items 1-3 of 3
-
Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.
(2017-11-13)Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy are needed for this large patient group. ... -
LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations.
(2021-08-20)Cell-free DNA (cfDNA) measured via liquid biopsies provides a way for minimally invasive monitoring of tumor evolutionary dynamics during therapy. Here we present liquidCNA, a method to track subclonal evolution from ... -
Measures of genetic diversification in somatic tissues at bulk and single-cell resolution.
(eLife Sciences Publications, 2024-01-24)Intra-tissue genetic heterogeneity is universal to both healthy and cancerous tissues. It emerges from the stochastic accumulation of somatic mutations throughout development and homeostasis. By combining population genetics ...