Browsing Centre for Tumour Biology by Subject "Genetic Heterogeneity"
Now showing items 1-2 of 2
-
How many samples are needed to infer truly clonal mutations from heterogenous tumours?
(2019-04-29)BACKGROUND: Modern cancer treatment strategies aim to target tumour specific genetic (or epigenetic) alterations. Treatment response improves if these alterations are clonal, i.e. present in all cancer cells within tumours. ... -
Measures of genetic diversification in somatic tissues at bulk and single-cell resolution.
(eLife Sciences Publications, 2024-01-24)Intra-tissue genetic heterogeneity is universal to both healthy and cancerous tissues. It emerges from the stochastic accumulation of somatic mutations throughout development and homeostasis. By combining population genetics ...