Browsing Centre for Tumour Biology by Subject "FOXO"

Now showing items 1-2 of 2

    • Antagonism between FOXO and MYC Regulates Cellular Powerhouse. 

      Peck, B; Ferber, EC; Schulze, A (Frontiers Media SA, 2013-04-25)
      Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromolecule synthesis is a prerequisite for rapid proliferation but may also contribute to induction of angiogenesis, metastasis ...

    • FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression 

      Ferber, EC; Peck, B; Delpuech, O; Bell, GP; East, P; Schulze, A (Macmillan Publishers, 2012-06)
      Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase/Akt pathway, and are key regulators of the cell cycle, apoptosis and response to oxidative stress. FOXOs have ...