Browsing Centre for Tumour Biology by Author "Lakatos, E"
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Evolutionary dynamics of neoantigens in growing tumours
Lakatos, E; Williams, M; Schenck, R; Cross, W; Househam, J; Werner, B; Gatenbee, C; Robertson-Tessi, M; Barnes, C; Anderson, A (2019-01-31)ABSTRACT Cancer evolution is driven by the acquisition of somatic mutations that provide cells with a beneficial phenotype in a changing microenvironment. However, mutations that give rise to neoantigens, novel cancer–specific ... -
LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations.
Lakatos, E; Hockings, H; Mossner, M; Huang, W; Lockley, M; Graham, TA (2021-08-20)Cell-free DNA (cfDNA) measured via liquid biopsies provides a way for minimally invasive monitoring of tumor evolutionary dynamics during therapy. Here we present liquidCNA, a method to track subclonal evolution from ... -
NeoPredPipe: high-throughput neoantigen prediction and recognition potential pipeline.
Schenck, RO; Lakatos, E; Gatenbee, C; Graham, TA; Anderson, ARA (2019-05-22)BACKGROUND: Next generation sequencing has yielded an unparalleled means of quickly determining the molecular make-up of patient tumors. In conjunction with emerging, effective immunotherapeutics for a number of cancers, ... -
NeoPredPipe: high-throughput neoantigen prediction and recognition potential pipeline.
Schenck, RO; Lakatos, E; Gatenbee, C; Graham, TA; Anderson, ARA (2019) -
Transition state characteristics during cell differentiation
Brackston, RD; Lakatos, E; Stumpf, MPH (Public Library of Science, 2018-09-20)Models describing the process of stem-cell differentiation are plentiful, and may offer insights into the underlying mechanisms and experimentally observed behaviour. Waddington’s epigenetic landscape has been providing a ...