Browsing Centre for Tumour Biology by Author "Lai, C-F"
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Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.
Harrod, A; Fulton, J; Nguyen, VTM; Periyasamy, M; Ramos-Garcia, L; Lai, C-F; Metodieva, G; de Giorgio, A; Williams, RL; Santos, DB (Springer Nature, 2017-04-20)Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating and reducing breast cancer progression in ER-positive disease. However, resistance to these therapies presents a major clinical ...