Browsing Centre for Tumour Biology by Author "Eccles, B"
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Genetic and immune landscape evolution in MMR-deficient colorectal cancer.
Challoner, BR; Woolston, A; Lau, D; Buzzetti, M; Fong, C; Barber, LJ; Anandappa, G; Crux, R; Assiotis, I; Fenwick, K (2023-11-15)Mismatch repair-deficient (MMRd) colorectal cancers (CRCs) have high mutation burdens, which make these tumours immunogenic and many respond to immune checkpoint inhibitors. The MMRd hypermutator phenotype may also promote ...