Browsing Centre for Tumour Biology by Author "East, P"
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FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
Ferber, EC; Peck, B; Delpuech, O; Bell, GP; East, P; Schulze, A (Macmillan Publishers, 2012-06)Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase/Akt pathway, and are key regulators of the cell cycle, apoptosis and response to oxidative stress. FOXOs have ... -
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.
Griffiths, B; Lewis, CA; Bensaad, K; Ros, S; Zhang, Q; Ferber, EC; Konisti, S; Peck, B; Miess, H; East, P (Springer Verlag, 2013-01-23)BACKGROUND: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated ...