Centre for Molecular Oncology: Recent submissions
Now showing items 161-180 of 272
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Germline variation at 8q24 and prostate cancer risk in men of European ancestry
(Nature Publishing Group, 2018-11-05)Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ... -
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
(Nature Publishing Group, 2017-12-01)Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide ... -
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.
(2018-10-04)Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS ... -
Genomic and transcriptomic approaches towards the genetic improvement of an underutilised crops: The case of Bambara groundnut
(Makerere University, 2016-12-02)With the world population estimated to be nine billion by 2050, the need to exploit plant genetic diversity in order to increase and diversify global food supply, and minimise the over-reliance for food on a few staple ... -
A Transcriptomic Comparison of Two Bambara Groundnut Landraces under Dehydration Stress
(MDPI, 2017-04-18)The ability to grow crops under low-water conditions is a significant advantage in relation to global food security. Bambara groundnut is an underutilised crop grown by subsistence farmers in Africa and is known to survive ... -
miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.
(2019-04)Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, ... -
CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
(American Association for Cancer Research, 2016-06-20)Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant ... -
Ovarian cancer in adolescents and young adults.
(Wiley, 2018-10-23)The diagnosis of ovarian cancer in adolescents and young adults is always challenging. Many issues exist, and most important of these may be access to care with an appropriate provider. A range of histologies occur in the ... -
Demographic, clinical, and pathological features of early onset pancreatic cancer patients.
(2018-09-12)BACKGROUND: Early onset pancreatic cancer (EOPC), i.e. pancreatic ductal adenocarcinoma (PDAC) occurring in patients below 50 years of age, is rare and there is limited information regarding risk factors, molecular basis ... -
Methods for monitoring and measurement of protein translation in time and space
(Royal Society of Chemistry, 2017-10-12)Regulation of protein translation constitutes a crucial step in control of gene expression. In comparison to transcriptional regulation, however, translational control has remained a significantly under-studied layer of ... -
The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer
(Impact Journals, 2018-10-09)Pimozide, an antipsychotic drug of the diphenylbutylpiperidine class, has been shown to suppress cell growth of breast cancer cells in vitro. In this study we further explore the inhibitory effects of this molecule in ... -
Non-random Mis-segregation of Human Chromosomes.
(2018-06-12)A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations ...