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SUMOylation is required for optimal TRAF3 signaling capacity.
(2013)
TNF receptor-associated factors (TRAFs) are multifunctional adaptor proteins involved in temporal and spatial coordination of signals necessary for normal immune function. Here, we report that TRAF3, a TRAF family member ...
Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer.
(2018-05-31)
To understand the mechanism of cellular stress in basal-parabasal layers of normal cervical epithelium and during different stages of cervical carcinoma, we analyzed the alterations (expression/methylation/copy number ...
MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells.
(2017-12-15)
Programmed death ligand-1 (PD-L1) is a critical regulator of T cell function contributing to peripheral immune tolerance. Although it has been shown that posttranscriptional regulatory mechanisms control PD-L1 expression ...
Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells.
(2016-08)
The airway epithelium is altered in respiratory disease and is thought to contribute to disease etiology. A caveat to disease research is that the technique of isolation of bronchial epithelial cells from patients is ...
miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.
(2019-04)
Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, ...
CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
(American Association for Cancer Research, 2016-06-20)
Other than an association with HPV infection, little is known
about the genetic alterations determining the development of
penile cancer. Although penile cancer is rare in the developed
world, it presents a significant ...