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Resolving the fibrotic niche of human liver cirrhosis at single-cell level
(Springer Nature, 2019-11-21)
Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular ...
Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
(2021-01)
BACKGROUND: Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment. A lack of tumor-infiltrating T cells is a common reason ...
Mapping Rora expression in resting and activated CD4+ T cells.
(Public Library of Science, 2021-05-18)
The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with ...
Developmental cell programs are co-opted in inflammatory skin disease.
(AAAS, 2021-01-22)
The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human ...