Browsing Centre for Haemato-Oncology by Subject "Embryo, Mammalian"
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Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs.
(2018-12-20)The embryonic site of definitive hematopoietic stem cell (dHSC) origination has been debated for decades. Although an intra-embryonic origin is well supported, the yolk sac (YS) contribution to adult hematopoiesis remains ... -
Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo.
(2017-07)Hematopoietic stem and progenitor cells (HSPCs) sustain life-long hematopoiesis and are first detected in the embryo by transplantation at embryonic day 10.5 (E10.5). HSPCs are mesodermal in origin and ultimately emerge ...