Browsing Centre for Haemato-Oncology by Title
Now showing items 173-192 of 217
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Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring
(Nature Publishing, 2020-01-20)Understanding how oncogenic mutations rewire regulatory-protein networks is important for rationalizing the mechanisms of oncogenesis and for individualizing anticancer treatments. We report a chemical phosphoproteomics ... -
Regulation and function of the palmitoyl-acyltransferase ZDHHC5.
(2021-01-08)Protein palmitoylation (S-acylation) has emerged as an important player in a range of cellular processes, and as a result, the palmitoyl-acyltransferase (PAT) enzymes which mediate this modification have entered into the ... -
Retinoic acid-responsive CD8 effector T-cells are selectively increased in IL-23-rich tissue in gastrointestinal GvHD.
(2020-09-09)Gastrointestinal (GI) graft-versus-host disease (GvHD) is a major barrier in allogeneic hematopoietic stem-cell transplantation (AHST). The metabolite retinoic acid (RA) potentiates GI-GvHD in mice via alloreactive T-cells ... -
Revising the Treatment Pathways in Lymphoma: New Standards of Care-How Do We Choose?
(2022-04)Diffuse large B-cell lymphoma and follicular lymphoma are the most commonly encountered non-Hodgkin lymphomas in clinical practice. Both are biologically heterogeneous, with management strategies that are becoming increasingly ... -
The Role of Csmd1 during Mammary Gland Development.
(MDPI, 2021-01-26)The Cub Sushi Multiple Domains-1 (CSMD1) protein is a tumour suppressor which has been shown to play a role in regulating human mammary duct development in vitro. CSMD1 knockdown in vitro demonstrated increased cell ... -
The Role of Metabolism in the Development of Personalized Therapies in Acute Myeloid Leukemia
(Frontiers Media, 2021-05-19)Despite significant recent advances in our understanding of the biology and genetics of acute myeloid leukemia (AML), current AML therapies are mostly based on a backbone of standard chemotherapy which has remained mostly ... -
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML.
(2023-10-27)KMT2A-rearranged (KMT2A-R) is an aggressive and chemo-refractory acute leukemia which mostly affects children. Transcriptomics-based characterization and chemical interrogation identified kinases as key drivers of survival ...