Browsing Centre for Haemato-Oncology by Title
Now showing items 72-91 of 217
-
Generation and Surgical Analysis of Genetic Mouse Models to Study NF-κB-Driven Pathogenesis of Diffuse Large B Cell Lymphoma.
(2021)Enforced activation of NF-κB signaling can be achieved by constitutive NF-κB-inducing kinases, IKK2 and NIK, or via lymphoma-associated mutants of MYD88, CARD11, and CD79B. In order to model Diffuse Large B Cell Lymphoma ... -
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukemia
(Nature Publishing Group, 2017-11-08)Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes ... -
The global clonal complexity of the murine blood system declines throughout life and after serial transplantation.
(2019-05-02)Although many recent studies describe the emergence and prevalence of "clonal hematopoiesis of indeterminate potential" in aged human populations, a systematic analysis of the numbers of clones supporting steady-state ... -
Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.
(2010-10-26)Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are ... -
Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders.
(Elsevier, 2024-01-20)Gene modification of haematopoietic stem cells (HSCs) is a potentially curative approach to sickle cell disease (SCD) and offers hope for patients who are not eligible for allogeneic HSC transplantation. Current approaches ... -
Hematopoietic stem cells under pressure.
(2017-07)PURPOSE OF REVIEW: Hematopoietic stem cells (HSCs) and progenitors are tasked with maintaining hematopoietic homeostasis in the face of numerous insults and challenges, including infection, inflammation, and exsanguination. ... -
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors.
(2017-11-13)Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is sufficient to drive cellular transformation is not clear. To investigate this question, we use a CRISPR-dCas9 epigenetic editing tool, ... -
HOXA9 and β-catenin safeguard HSC integrity.
(American Society of Hematology, 2024-04-18) -
Human mesenchymal stromal cells deliver systemic oncolytic measles virus to treat acute lymphoblastic leukemia in the presence of humoral immunity.
(2014-02-27)Clinical trials of oncolytic attenuated measles virus (MV) are ongoing, but successful systemic delivery in immune individuals remains a major challenge. We demonstrated high-titer anti-MV antibody in 16 adults with acute ...