Browsing Centre for Haemato-Oncology by Title
Now showing items 193-212 of 217
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Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis
(Oxford University Press, 2018-07-06) -
Spotlight On Early Career Researchers: an interview with Lovorka Stojic
(Springer Nature, 2019-06-14) -
Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo.
(2010-05-27)Surface IgM (sIgM) has a key influence on the clinical behavior of chronic lymphocytic leukemia (CLL). We now report that it exists in 2 forms with different N-glycosylation patterns in the mu-constant region. One glycoform ... -
Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.
(2012-01-05)Although long considered as a disease of failed apoptosis, it is now clear that chronic lymphocytic leukemia (CLL) cells undergo extensive cell division in vivo, especially in progressive disease. Signaling via the B-cell ... -
Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma
(American Society of Hematology, 2020-11-05) -
Transcriptional profiling identifies differential expression of long non-coding RNAs in Jo-1 associated and inclusion body myositis.
(2017-08-14)Myositis is characterised by muscle inflammation and weakness. Although generally thought to be driven by a systemic autoimmune response, increasing evidence suggests that intrinsic changes in the muscle might also contribute ... -
UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia.
(2014-02-06)The Philadelphia chromosome positive arm of the UKALLXII/ECOG2993 study for adult acute lymphoblastic leukemia (ALL) enrolled 266 patients between 1993 and 2003 (pre-imatinib cohort). In 2003 imatinib was introduced as a ...