Browsing Barts Cancer Institute by Subject "cancer"
Now showing items 1-18 of 18
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The 2019 Mathematical Oncology Roadmap.
(IOP Publishing, 2019-04-16)Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology, Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is no denying that mathematics continues to ... -
Antagonism between FOXO and MYC Regulates Cellular Powerhouse.
(Frontiers Media SA, 2013-04-25)Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromolecule synthesis is a prerequisite for rapid proliferation but may also contribute to induction of angiogenesis, metastasis ... -
Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies.
(2023-09-18)Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy can be present in a static state: Down ... -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
(2021-02-08)In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ... -
The Identification and Interpretation of cis-Regulatory Noncoding Mutations in Cancer
(MDPI, 2018-12-20)In the need to characterise the genomic landscape of cancers and to establish novel biomarkers and therapeutic targets, studies have largely focused on the identification of driver mutations within the protein-coding gene ... -
Measuring Clonal Evolution in Cancer with Genomics.
(2019-08-31)Cancers originate from somatic cells in the human body that have accumulated genetic alterations. These mutations modify the phenotype of the cells, allowing them to escape the homeostatic regulation that maintains normal ... -
Optimizing arginine deprivation for hard-to-treat cancers.
(2017-11-14) -
PEOPLE: PatiEnt prOstate samPLes for rEsearch, a tissue collection pathway utilizing magnetic resonance imaging data to target tumor and benign tissue in fresh radical prostatectomy specimens.
(2019-05)BACKGROUND: Over 1 million men are diagnosed with prostate cancer each year worldwide, with a wide range of research programs requiring access to patient tissue samples for development of improved diagnoses and treatments. ...