Browsing Barts Cancer Institute by Title
Now showing items 944-963 of 1159
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A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma
(Springer, 2023-04-03)Background Pegylated arginine deiminase (ADI-PEG20; pegargiminase) depletes arginine and improves survival outcomes for patients with argininosuccinate synthetase 1 (ASS1)-deficient malignant pleural mesothelioma (MPM). ... -
A role for the cancer-associated miR-106b similar to 25 cluster in neuronal stem cells
(Impact Journals, 2011-04)In the last decade, micro-RNAs (miRNAs) have emerged as major regulators of cell fate. They are involved in fine-tuning gene expression in normal developing tissues and are often aberrantly expressed in different disease ... -
The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma.
(2020-10-22)Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cancer cells, contributing to carcinogenesis and the tumour microenvironment. Recent studies have revealed that CAFs, normal ... -
The role of colorectal cancer plasticity in metastasis and treatment: an interview with Mirjana Efremova
(Future Science Group, 2023-12-01) -
The Role of Csmd1 during Mammary Gland Development.
(MDPI, 2021-01-26)The Cub Sushi Multiple Domains-1 (CSMD1) protein is a tumour suppressor which has been shown to play a role in regulating human mammary duct development in vitro. CSMD1 knockdown in vitro demonstrated increased cell ... -
The Role of Metabolism in the Development of Personalized Therapies in Acute Myeloid Leukemia
(Frontiers Media, 2021-05-19)Despite significant recent advances in our understanding of the biology and genetics of acute myeloid leukemia (AML), current AML therapies are mostly based on a backbone of standard chemotherapy which has remained mostly ... -
The role of single-cell sequencing in studying tumour evolution.
(2021-05-26)Tumour evolution is a complex interplay between the acquisition of somatic (epi)genomic changes in tumour cells and the phenotypic consequences they cause, all in the context of a changing microenvironment. Single-cell ...