Browsing Barts Cancer Institute by Title
Now showing items 120-139 of 1165
-
A cancer-associated, genome protective programme engaging PKCε.
(2020-12)Associated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great ... -
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.
(2017-06-01)BACKGROUND: Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but ... -
Cdk7: open questions beyond the prevailing model.
(2012-10-01) -
Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications.
(2023-12-04)DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and is essential for the separation of replicated sister chromatids and the integrity of cell division. Topo IIA dysfunction activates ... -
Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die - that is the question
(2012-04)Death rules our lives. In this short paper, we summarize new insights into molecular mechanisms of neurodegeneration. Here we review the most important processes of cell death: apoptosis and oncosis. We focus on autophagy, ... -
Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis.
(BioMed Central, 2018-11-21)BACKGROUND: There are multiple existing and emerging therapeutic avenues for metastatic prostate cancer, with a common denominator, which is the need for predictive biomarkers. Circulating tumor DNA (ctDNA) has the potential ... -
Cells are Us - combining research and public engagement
(2021-03-24)