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Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

dc.contributor.authorCorbin, LJen_US
dc.contributor.authorTan, VYen_US
dc.contributor.authorHughes, DAen_US
dc.contributor.authorWade, KHen_US
dc.contributor.authorPaul, DSen_US
dc.contributor.authorTansey, KEen_US
dc.contributor.authorButcher, Fen_US
dc.contributor.authorDudbridge, Fen_US
dc.contributor.authorHowson, JMen_US
dc.contributor.authorJallow, MWen_US
dc.contributor.authorJohn, Cen_US
dc.contributor.authorKingston, Nen_US
dc.contributor.authorLindgren, CMen_US
dc.contributor.authorO'Donavan, Men_US
dc.contributor.authorO'Rahilly, Sen_US
dc.contributor.authorOwen, MJen_US
dc.contributor.authorPalmer, CNAen_US
dc.contributor.authorPearson, ERen_US
dc.contributor.authorScott, RAen_US
dc.contributor.authorvan Heel, DAen_US
dc.contributor.authorWhittaker, Jen_US
dc.contributor.authorFrayling, Ten_US
dc.contributor.authorTobin, MDen_US
dc.contributor.authorWain, LVen_US
dc.contributor.authorSmith, GDen_US
dc.contributor.authorEvans, DMen_US
dc.contributor.authorKarpe, Fen_US
dc.contributor.authorMcCarthy, MIen_US
dc.contributor.authorDanesh, Jen_US
dc.contributor.authorFranks, PWen_US
dc.contributor.authorTimpson, NJen_US
dc.date.accessioned2018-02-26T10:58:46Z
dc.date.available2018-01-19en_US
dc.date.issued2018-02-19en_US
dc.date.submitted2018-01-19T11:37:25.637Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/33623
dc.description.abstractDetailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the application of RbG: studies using single variants and those using multiple variants. We consider the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner.en_US
dc.description.sponsorshipMedical Research Councilen_US
dc.format.extent711 - ?en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofNat Communen_US
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.subjectCausalityen_US
dc.subjectGenetic Variationen_US
dc.subjectGenome-Wide Association Studyen_US
dc.subjectGenotypeen_US
dc.subjectHumansen_US
dc.subjectMolecular Epidemiologyen_US
dc.subjectPhenotypeen_US
dc.subjectRisk Factorsen_US
dc.subjectUnited Kingdomen_US
dc.titleFormalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.en_US
dc.typeArticle
dc.rights.holder(c) The Author(s), 2018.
dc.identifier.doi10.1038/s41467-018-03109-yen_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29459775en_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume9en_US
dcterms.dateAccepted2018-01-19en_US


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