Browsing Centre for Cancer Prevention by Subject "Mutation"

Now showing items 1-2 of 2

    • Clone competition as a mechanism to reduce tumor formation. 

      Acha-Sagredo, A; Malanchi, I; Ciccarelli, FD (2021-12-20)
      With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between ...

    • Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. 

      Mencacci, NE; Isaias, IU; Reich, MM; Ganos, C; Plagnol, V; Polke, JM; Bras, J; Hersheson, J; Stamelou, M; Pittman, AM (2014-09)
      GTP cyclohydrolase 1, encoded by the GCH1 gene, is an essential enzyme for dopamine production in nigrostriatal cells. Loss-of-function mutations in GCH1 result in severe reduction of dopamine synthesis in nigrostriatal ...