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Now showing items 1071-1076 of 1076
NMR metabolomic modeling of age and lifespan: A multicohort analysis.
(Wiley, 2024-04-18)
Metabolomic age models have been proposed for the study of biological aging, however, they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance ...
Pathogenic <i>SPTBN1</i> variants cause an autosomal dominant neurodevelopmental syndrome
(Nature Research, 2021-07-01)
SPTBN1 encodes βII-spectrin, the ubiquitously expressed β-spectrin that forms micrometer-scale networks associated with plasma membranes. Mice deficient in neuronal βII-spectrin have defects in cortical organization, ...
Expert Panel Review of alternative biological matrices for use as an evidential sample for drug driving
(The United Kingdom Department for Transport, 2017-08-21)
Executive Summary 1 METHODOLOGY AND ANALYTICAL TECHNIQUES AVAILABLE FOR THE DETECTION OF DRUGS INCLUDED IN THE DRUG-DRIVING LEGISLATION It is standard practice in Forensic Science for the methodology employed for the ...
Quantifying stochasticity in the aging DNA methylome.
(Nature Research, 2024-05-16)
Aging-related DNA methylation changes are numerous. Their precise measurement has opened new avenues to explore aging-related disease pathology, including the construction of chronological and biological age predictors ...
Identification and characterisation of functional Kir6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane.
(2024-05-19)
BACKGROUND AND PURPOSE: The canonical Kir6.2/SUR2A ventricular KATP channel is highly ATP-sensitive and remains closed under normal physiological conditions. These channels activate only when prolonged metabolic compromise ...
Sex-Specific Effects of Blood Pressure Lowering Pharmacotherapy for the Prevention of Cardiovascular Disease: An Individual Participant-Level Data Meta-Analysis.
(2023-11)
BACKGROUND: Whether the relative effects of blood pressure (BP)-lowering treatment on cardiovascular outcomes differ by sex, particularly when BP is not substantially elevated, has been uncertain. METHODS: We conducted an ...