Browsing Centre for Clinical Pharmacology by Title
Now showing items 1035-1054 of 1057
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Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression.
(2020-04)OBJECTIVES: This study sought to examine the utility of multimodality intravascular imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution. BACKGROUND: There is robust evidence ... -
Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate.
(2018-08-01)Traditionally, bioanalytical laboratories do not report actual concentrations for samples with results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method calibration range established during ... -
Validation of the all-comers design: Results of the TARGET-AC substudy.
(2020-03)BACKGROUND: Results of clinical trials are often criticized by low inclusion rate and potential sampling bias in patient recruitment. The aim of this validation registry is to evaluate how far an all-comers design in the ... -
Variable selection and risk prediction using a penalised modelling framework for high-dimensional data in a nested matched case-control design
(https://rss.org.uk/training-events/conference2022/, 2022-09-12)In a matched case-control (MCC) study, each subject with the outcome of interest (case) is matched with m subjects without the outcome (control) from the same cohort (often called a 1:m nested MCC). This design is efficient ... -
Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis
(Oxford University Press (OUP), 2020-05-27) -
Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study
(2020-09-09)Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/thy.2020.0393. -
Weather, day length and physical activity in older adults: Cross-sectional results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk Cohort.
(2017)BACKGROUND: A wide range of environmental factors have been related to active ageing, but few studies have explored the impact of weather and day length on physical activity in older adults. We investigate the cross-sectional ... -
Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?
(2020-09-13)© 2020 Creative Commons; the authors hold their copyright. Precision medicine has been heralded as an opportunity to improve risk prediction, driven significantly by an increasing availability of genetic data. Genetic ... -
Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal study.
(2024-01-27)BACKGROUND: Atypical temporal work patterns such as working longer than the standard 35-40 h/ week, weekend working, and nonstandard work schedules (i.e. outside of the typical 9-5, including but not restricted to shiftwork) ...