Browsing Centre for Clinical Pharmacology by Title
Now showing items 679-698 of 1055
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The narrow-sense and common single nucleotide polymorphism heritability of early repolarization.
(2019-03-15)BACKGROUND: Early repolarization (ER) is a risk marker for sudden cardiac death. Higher risk is associated with horizontal/descending ST-segment ER in the inferior or inferolateral ECG leads. Studies in family cohorts have ... -
Neointima and neoatherosclerotic characteristics in bare metal and first- and second-generation drug-eluting stents in patients admitted with cardiovascular events attributed to stent failure: an optical coherence tomography study.
(2018-02-02)AIMS: The aim of this study was to assess neoatherosclerotic plaque morphology in bare metal (BMS) and first- and second-generation drug-eluting stents (DES) in patients presenting with an event attributed to stent failure. ... -
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases.
(2017-09)Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a ... -
Neuromuscular taping reduces blood pressure in systemic arterial hypertension
(Elsevier, 2018-04-17) -
Neutrophil Elastase Promotes Neointimal Hyperplasia by Targeting TLR4-NFкB Signalling.
(Wiley, 2021-06-02)BACKGROUND AND PURPOSE: Neointimal hyperplasia (NIH) is the fundamental cause for vascular diseases, and vascular smooth muscle cell (VSMC) dysregulation has been widely implicated in NIH. Neutrophil elastase (NE) has been ... -
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
(American Heart Association, 2017-10-13)Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ... -
New Insights into Kleefstra Syndrome: Report of Two Novel Cases with Previously Unreported Features and Literature Review.
(2018)Kleefstra syndrome (KS) is a rare genetic condition resulting from either 9q34.3 microdeletions or mutations in the EHMT1 gene located in the same genomic region. To date, approximately 100 patients have been reported, ... -
A New Radically Improved Model of the Circulation With Important Clinical Implications
(Annals of Clinical and Medical Case Reports, 2020) -
A new test for trait mean and variance detects unreported loci for blood-pressure variation.
(Elsevier, 2024-04-12)Variability in quantitative traits has clinical, ecological, and evolutionary significance. Most genetic variants identified for complex quantitative traits have only a detectable effect on the mean of trait. We have ...