Browsing Centre for Translational Medicine & Therapeutics by Subject "senescence"

Now showing items 1-4 of 4

    • Aged-senescent cells contribute to impaired heart regeneration 

      Lewis-McDougall, FC; RUCHAYA, PJ; Domenjo-Vila, E; Teoh, TS; Prata, L; Cottle, BJ; Clark, JE; Punjabi, PP; Awad, W; Torella, D (Wiley Online, 2019-03-10)
      Aging leads to increased cellular senescence and is associated with decreased potency of tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human ...

    • Mitochondrial Dysfunction Accelerates Ageing. 

      Schroth, J; Henson, SM (2020-10-16)
      We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add ...

    • Mitochondrial mass governs the extent of human T cell senescence 

      Callender, LA; Carroll, EC; Bober, EA; Akbar, AN; Solito, E; Henson, SM (Wiley Online, 2019-12-02)
      The susceptibility of human CD4+ and CD8+ T cells to senesce differs, with CD8+ T cells acquiring an immunosenescent phenotype faster than the CD4+ T cell compartment. We show here that it is the inherent difference in ...

    • Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease 

      Schroth, J; Thiemermann, C; Henson, SM (2020-10-09)