Centre for Microvascular Research (CMR): Recent submissions
Now showing items 21-40 of 104
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The dimeric form of CXCL12 binds to atypical chemokine receptor 1
(American Association for the Advancement of Science (AAAS), 2021-08-17)The pleiotropic chemokine CXCL12 is involved in diverse physiological and pathophysiological processes, including embryogenesis, hematopoiesis, leukocyte migration, and tumor metastasis. It is known to engage the classical ... -
CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues.
(2021-06-03)Acute myeloid leukemia (AML) has a poor prognosis under the current standard of care. In recent years, venetoclax, a BCL-2 inhibitor, was approved to treat patients, ineligible for intensive induction chemotherapy. Complete ... -
CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity.
(Ferrata Storti Foundation, 2020-07-02)Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell adhesion in bone ... -
The role of CD44 in the pathophysiology of chronic lymphocytic leukemia
(Frontiers Media, 2015-04-20)CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of CD44 standard and variant forms and ... -
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia
(Taylor & Francis, 2017-09-21)While research on T cell exhaustion in context of cancer particularly focuses on CD8C cytotoxic T cells, the role of inhibitory receptors on CD4C T-helper cells have remained largely unexplored. TIGIT is a recently identified ... -
TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia
(Springer Nature, 2020-02-21) -
Mesenchymal stem/stromal cell therapy for pulmonary arterial hypertension: Comprehensive review of preclinical studies.
(2019-10)Pulmonary arterial hypertension (PAH) is a disease characterized by progressive pulmonary vascular remodeling, resulting in right-sided heart failure and premature death. Current available therapies for PAH have limited ... -
Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
(Elsevier Inc., 2021-05-24)Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in inflamed aged tissues neutrophils exhibited ... -
A feeder-free, human plasma-derived hydrogel for maintenance of a human embryonic stem cell phenotype in vitro.
(BioMed Central Ltd., 2012-08-08)BACKGROUND: Human embryonic stem cells (hESCs) represent a tremendous resource for cell therapies and the study of human development; however to maintain their undifferentiated state in vitro they routinely require the use ... -
Evaluation of a novel non-destructive catch and release technology for harvesting autologous adult stem cells.
(Public Library of Science, 2013-01-22)BACKGROUND: Cell based therapies are required now to meet the critical care needs of paediatrics and healthy ageing in an increasingly long-lived human population. Repair of compromised tissue by supporting autologous ... -
Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy.
(2014-03-26)BACKGROUND: Diabetes mellitus (DM) has multifactorial detrimental effects on myocardial tissue. Recently, carbonic anhydrases (CAs) have been shown to play a major role in diabetic microangiopathy but their role in the ... -
The evolving role of preprints in the dissemination of COVID-19 research and their impact on the science communication landscape
(Public Library of Science, 2021-04)The world continues to face a life-threatening viral pandemic. The virus underlying the Coronavirus Disease 2019 (COVID-19), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has caused over 98 million confirmed ... -
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
(2021-03-30)RATIONALE: The receptor-like protein tyrosine phosphatase eta (CD148/PTPRJ) exerts anti-fibrotic effects in experimental pulmonary fibrosis via interactions with its ligand syndecan-2; however, the role of CD148 in human ... -
A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration
(Rockefeller University Press, 2007-12-17) -
Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy
(2019-08-02)Meeting Abstract: 718 from 14th Annual American-Heart-Association's Basic Cardiovascular Sciences (BCVS) Scientific Sessions , Boston, MA. JUL 29-AUG 01, 2019