Browsing Centre for Microvascular Research (CMR) by Author "White, IJ"

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    • Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration 

      Kostelnik, KB; Barker, A; Schultz, C; Mitchell, TP; Rajeeve, V; White, IJ; Aurrand-Lions, M; Nourshargh, S; Cutillas, P; Nightingale, TD (Public Library of Science, 2019-12-02)
      Junctional complexes between endothelial cells form a dynamic barrier that hinders passive diffusion of blood constituents into interstitial tissues. Remodelling of junctions is an essential process during leukocyte ...

    • Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade Bodies. 

      NIGHTINGALE, TD; McCormack, JJ; Grimes, W; ROBINSON, C; Lopes da Silva, M; White, IJ; Vaughan, A; Cramer, LP; Cutler, DF (Wiley, 2018-06-28)
      BACKGROUND: Endothelial cells harbour specialised storage organelles, Weibel-Palade Bodies (WPBs). Exocytosis of WPB content into the vascular lumen initiates primary haemostasis, mediated by Von Willebrands factor (VWF) ...

    • Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade bodies. 

      Nightingale, TD; McCormack, JJ; Grimes, W; Robinson, C; Lopes da Silva, M; White, IJ; Vaughan, A; Cramer, LP; Cutler, DF (2018-09)
      Essentials Endothelial activation initiates multiple processes, including hemostasis and inflammation. The molecules that contribute to these processes are co-stored in secretory granules. How can the cells control release ...