Browsing Centre for Microvascular Research (CMR) by Author "Owen-Woods, C"
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Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
Barkaway, A; Rolas, L; Joulia, R; Bodkin, J; Lenn, T; Owen-Woods, C; Reglero-Real, N; Stein, M; Vazquez Martinez, L; Girbl, T (Elsevier Inc., 2021-05-24)Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in inflamed aged tissues neutrophils exhibited ... -
Local microvascular leakage promotes trafficking of activated neutrophils to remote organs.
Owen-Woods, C; Joulia, R; Barkaway, A; Rolas, L; Ma, B; Nottebaum, AF; Arkill, KP; Stein, M; Girbl, T; Golding, M (2020-03-23)Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, ...