Browsing Centre for Microvascular Research (CMR) by Author "Nourshargh, S"
Now showing items 1-20 of 32
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Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
Barkaway, A; Rolas, L; Joulia, R; Bodkin, J; Lenn, T; Owen-Woods, C; Reglero-Real, N; Stein, M; Vazquez Martinez, L; Girbl, T (Elsevier Inc., 2021-05-24)Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy, we found that in inflamed aged tissues neutrophils exhibited ... -
Angiogenesis associated macrophages support elevated acute inflammatory responses
Ma, B; Whiteford, JR; Nourshargh, S; Woodfin, A (2015-05) -
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Reglero, N; Pérez-Gutiérrez, L; Yoshimura, A; Rolas, L; Garrido-Mesa, J; Barkaway, A; PICKWORTH, C; Saleeb, R; Gonzalez-Nuñez, M; Austin-Williams, SN (Elsevier, 2021-08-06)The migration of neutrophils from the blood circulation to sites of infection or injury is a key immune response and requires the breaching of endothelial cells (ECs) that line the inner aspect of blood vessels. ... -
Cardiovascular Progerin Suppression and lamin A Restoration Rescues Hutchinson-Gilford Progeria Syndrome.
Sánchez-López, A; Espinós-Estévez, C; González-Gómez, C; Gonzalo, P; Andrés-Manzano, MJ; Fanjul, V; Riquelme-Borja, R; Hamczyk, MR; Macías, Á; Del Campo, L (Wolters Kluwer Health, Inc., 2021-10-25)Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by premature aging and death mainly due to myocardial infarction, stroke, or heart failure. The disease is provoked by progerin, a ... -
Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.
Schulz-Fincke, A-C; Tikhomirov, AS; Braune, A; Girbl, T; Gilberg, E; Bajorath, J; Blaut, M; Nourshargh, S; Gütschow, M (2018-02-06)Human neutrophil elastase is an important regulator of the immune response and plays a role in host defense mechanisms and further physiological processes. The uncontrolled activity of this serine protease may cause severe ... -
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis.
Girbl, T; Lenn, T; Perez, L; Rolas, L; Barkaway, A; Thiriot, A; Del Fresno, C; Lynam, E; Hub, E; Thelen, M (2018-12-18)Neutrophils require directional cues to navigate through the complex structure of venular walls and into inflamed tissues. Here we applied confocal intravital microscopy to analyze neutrophil emigration in cytokine-stimulated ... -
Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration
Kostelnik, KB; Barker, A; Schultz, C; Mitchell, TP; Rajeeve, V; White, IJ; Aurrand-Lions, M; Nourshargh, S; Cutillas, P; Nightingale, TD (Public Library of Science, 2019-12-02)Junctional complexes between endothelial cells form a dynamic barrier that hinders passive diffusion of blood constituents into interstitial tissues. Remodelling of junctions is an essential process during leukocyte ... -
Endogenous TNF alpha orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation
Arokiasamy, S; Zakian, C; Dilliway, J; Wang, W; Nourshargh, S; Voisin, M-B (2017-03-13) -
Endothelial cell autophagy keeps neutrophil trafficking under control
Reglero-Real, N; Perez-Gutierrez, L; Nourshargh, S (2021) -
Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation
Reglero-Real, N; Colom, B; Bodkin, JV; Nourshargh, S (2016-10) -
Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells
Benedicto, I; Carmona, RM; Barettino, A; Espinós-Estévez, C; Gonzalo, P; Nevado, RM; de la Fuente-Pérez, M; Andrés-Manzano, MJ; González-Gómez, C; Rolas, LHutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by the expression of progerin, a mutant protein that accelerates aging and precipitates death. Given that atherosclerosis complications are the main cause ... -
Guidelines for the use of flow cytometry and cell sorting in immunological studies
Cossarizza, A; Chang, H-D; Radbruch, A; Akdis, M; Andrae, I; Annunziato, F; Bacher, P; Barnaba, V; Battistini, L; Bauer, WM (2017-10) -
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza, A; Chang, H-D; Radbruch, A; Acs, A; Adam, D; Adam-Klages, S; Agace, WW; Aghaeepour, N; Akdis, M; Allez, M (2019-10) -
Heparanase-Dependent Remodeling of Initial Lymphatic Glycocalyx Regulates Tissue-Fluid Drainage During Acute Inflammation in vivo
Arokiasamy, S; King, R; Boulaghrasse, H; Nourshargh, S; Wang, W; Voisin, M-B (2019-10-04) -
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Cacho-Navas, C; López-Pujante, C; Reglero-Real, N; Colás-Algora, N; Cuervo, A; Conesa, JJ; Barroso, S; de Rivas, G; Ciordia, S; Paradela, A (eLife Sciences Publications, Ltd, 2024-04-10)Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile ... -
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Cacho-Navas, C; López-Pujante, C; Reglero-Real, N; Colás-Algora, N; Cuervo, A; Conesa, JJ; Barroso, S; de Rivas, G; Ciordia, S; Paradela, A (eLife, 2024-04-10)Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile ... -
Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome
Marcos-Ramiro, B; Gil-Ordonez, A; Marin-Ramos, NI; Ortega-Nogales, FJ; Balabasquer, M; Gonzalo, P; Khiar-Fernandez, N; Rolas, L; Barkaway, A; Nourshargh, S (2021) -
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
Woodfin, A; Voisin, MB; Beyrau, M; Colom, B; Caille, D; Diapouli, FM; Nash, GB; Chavakis, T; Albelda, SM; Rainger, GE (2011-08)The migration of neutrophils into inflamed tissues is a fundamental component of innate immunity. A decisive step in this process is the polarized migration of blood neutrophils through endothelial cells (ECs) lining the ... -
Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments
Barzilai, S; Yadav, SK; Morrell, S; Roncato, F; Klein, E; Stoler-Barak, L; Golani, O; Feigelson, SW; Zemel, A; Nourshargh, S (2017-01-17) -
Leukotriene B-4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo
Colom, B; Bodkin, JV; Beyrau, M; Woodfin, A; Ody, C; Rourke, C; Chavakis, T; Brohi, K; Imhof, BA; Nourshargh, S (2015-06-16)