Browsing Centre for Microvascular Research (CMR) by Author "Nightingale, TD"
Now showing items 1-7 of 7
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Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration
Kostelnik, KB; Barker, A; Schultz, C; Mitchell, TP; Rajeeve, V; White, IJ; Aurrand-Lions, M; Nourshargh, S; Cutillas, P; Nightingale, TD (Public Library of Science, 2019-12-02)Junctional complexes between endothelial cells form a dynamic barrier that hinders passive diffusion of blood constituents into interstitial tissues. Remodelling of junctions is an essential process during leukocyte ... -
Emerging mechanisms to modulate VWF release from endothelial cells
El-Mansi, S; Nightingale, TD (2021) -
Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence
Carpintero-Fernandez, P; Borghesan, M; Eleftheriadou, O; Pan-Castillo, B; Antonio Fafian-Labora, J; Mitchell, TP; Yuste, A; Ogrunc, M; Nightingale, TD; Mayan, M (2022) -
Myosin-1C augments secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane.
El-Mansi, S; Mitchell, TP; Mobyen, G; McKinnon, TA; Miklavc, P; Frick, M; Nightingale, TD (American Society of Hematology (ASH Publications), 2024-04-26)Blood endothelial cells control the hemostatic and inflammatory response by secreting von Willebrand factor (VWF) and P-selectin from storage organelles called Weibel-Palade bodies (WPB). Actin-associated motor proteins ... -
Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor
El-Mansi, S; Robinson, CL; Kostelnik, KB; McCormack, JJ; Mitchell, TP; Lobato-Marquez, D; Rajeeve, V; Cutillas, P; Cutler, DF; Mostowy, S (2023) -
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
Rolas, L; Stein, M; Barkaway, A; Reglero, N; Sciacca, E; Yaseen, M; Wang, H; Vazquez-Martinez, L; Golding, M; Blacksell, IA (EMBO Press, 2024-06-25)Cellular senescence is a hallmark of advanced age and a major instigator of numerous inflammatory pathologies. Whilst endothelial cell (EC) senescence is aligned with defective vascular functionality, its impact on fundamental ... -
Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade bodies.
Nightingale, TD; McCormack, JJ; Grimes, W; Robinson, C; Lopes da Silva, M; White, IJ; Vaughan, A; Cramer, LP; Cutler, DF (2018-09)Essentials Endothelial activation initiates multiple processes, including hemostasis and inflammation. The molecules that contribute to these processes are co-stored in secretory granules. How can the cells control release ...