Browsing Centre for Microvascular Research (CMR) by Author "Legler, DF"

Now showing items 1-2 of 2

    • CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity. 

      Gutjahr, JC; Bayer, E; Yu, X; Laufer, JM; Höpner, JP; Tesanovic, S; Härzschel, A; Auer, G; Rieß, T; Salmhofer, A (Ferrata Storti Foundation, 2020-07-02)
      Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell adhesion in bone ...

    • The dimeric form of CXCL12 binds to atypical chemokine receptor 1 

      Gutjahr, JC; Crawford, KS; Jensen, DR; Naik, P; Peterson, FC; Samson, GPB; Legler, DF; Duchene, J; Veldkamp, CT; Rot, A (American Association for the Advancement of Science (AAAS), 2021-08-17)
      The pleiotropic chemokine CXCL12 is involved in diverse physiological and pathophysiological processes, including embryogenesis, hematopoiesis, leukocyte migration, and tumor metastasis. It is known to engage the classical ...