Browsing Centre for Microvascular Research (CMR) by Author "Grimes, W"
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Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade Bodies.
NIGHTINGALE, TD; McCormack, JJ; Grimes, W; ROBINSON, C; Lopes da Silva, M; White, IJ; Vaughan, A; Cramer, LP; Cutler, DF (Wiley, 2018-06-28)BACKGROUND: Endothelial cells harbour specialised storage organelles, Weibel-Palade Bodies (WPBs). Exocytosis of WPB content into the vascular lumen initiates primary haemostasis, mediated by Von Willebrands factor (VWF) ... -
Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade bodies.
Nightingale, TD; McCormack, JJ; Grimes, W; Robinson, C; Lopes da Silva, M; White, IJ; Vaughan, A; Cramer, LP; Cutler, DF (2018-09)Essentials Endothelial activation initiates multiple processes, including hemostasis and inflammation. The molecules that contribute to these processes are co-stored in secretory granules. How can the cells control release ...