Browsing Centre for Microvascular Research (CMR) by Author "Greil, R"
Now showing items 1-5 of 5
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CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity.
Gutjahr, JC; Bayer, E; Yu, X; Laufer, JM; Höpner, JP; Tesanovic, S; Härzschel, A; Auer, G; Rieß, T; Salmhofer, A (Ferrata Storti Foundation, 2020-07-02)Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell adhesion in bone ... -
CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues.
Yu, X; Munoz-Sagredo, L; Streule, K; Muschong, P; Bayer, E; Walter, RJ; Gutjahr, JC; Greil, R; Concha, ML; Müller-Tidow, C (2021-06-03)Acute myeloid leukemia (AML) has a poor prognosis under the current standard of care. In recent years, venetoclax, a BCL-2 inhibitor, was approved to treat patients, ineligible for intensive induction chemotherapy. Complete ... -
The role of CD44 in the pathophysiology of chronic lymphocytic leukemia
Gutjahr, JC; Greil, R; Hartmann, TN (Frontiers Media, 2015-04-20)CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of CD44 standard and variant forms and ... -
TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia
Szenes, E; Haerzschel, A; Decker, S; Tissino, E; Pischeli, J; Gutjahr, JC; Kissel, S; Pennisi, S; Hoepner, JP; Egle, A (Springer Nature, 2020-02-21) -
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia
Catakovic, K; Gassner, FJ; Ratswohl, C; Zaborsky, N; Rebhandl, S; Schubert, M; Steiner, M; Gutjahr, JC; Pleyer, L; Egle, A (Taylor & Francis, 2017-09-21)While research on T cell exhaustion in context of cancer particularly focuses on CD8C cytotoxic T cells, the role of inhibitory receptors on CD4C T-helper cells have remained largely unexplored. TIGIT is a recently identified ...