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Shed syndecan-2 inhibits angiogenesis
(2014-11-01)
Local microvascular leakage promotes trafficking of activated neutrophils to remote organs.
(2020-03-23)
Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, ...
A degradatory fate for CCR4 suggests a primary role in Th2 inflammation.
(2020-03)
CCR4 is the sole receptor for the chemokines CCL22 and CCL17. Clinical studies of asthmatic airways have shown levels of both ligands and CCR4+ Th2 cells to be elevated, suggestive of a role in disease. Consequently, CCR4 ...