Browsing Centre for Biochemical Pharmacology by Subject "Rats, Wistar"

Now showing items 1-2 of 2

    • The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. 

      Khan, AI; Kapoor, A; Chen, J; Martin, L; Rogazzo, M; Mercier, T; Decosterd, L; Collino, M; Thiemermann, C (2018-06)
      Ischemic heart disease remains the leading cause of morbidity and mortality in the Western world. Artesunate is the WHO-recommended drug of choice for complicated malaria (with organ failure). The administration of high ...

    • Intracellular sodium elevation reprograms cardiac metabolism. 

      Aksentijević, D; Karlstaedt, A; Basalay, MV; O'Brien, BA; Sanchez-Tatay, D; Eminaga, S; Thakker, A; Tennant, DA; Fuller, W; Eykyn, TR (2020-08-28)
      Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Nai ...