Browsing Centre for Biochemical Pharmacology by Subject "Isolated Heart Preparation"

Now showing items 1-2 of 2

    • Intracellular sodium elevation reprograms cardiac metabolism. 

      Aksentijević, D; Karlstaedt, A; Basalay, MV; O'Brien, BA; Sanchez-Tatay, D; Eminaga, S; Thakker, A; Tennant, DA; Fuller, W; Eykyn, TR (2020-08-28)
      Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Nai ...

    • Structural basis for a complex I mutation that blocks pathological ROS production. 

      Yin, Z; Burger, N; Kula-Alwar, D; Aksentijević, D; Bridges, HR; Prag, HA; Grba, DN; Viscomi, C; James, AM; Mottahedin, A (2021-01-29)
      Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point ...