Browsing Centre for Biochemical Pharmacology by Subject "Isolated Heart Preparation"
Now showing items 1-2 of 2
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Intracellular sodium elevation reprograms cardiac metabolism.
(2020-08-28)Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Nai ... -
Structural basis for a complex I mutation that blocks pathological ROS production.
(2021-01-29)Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point ...