Browsing Centre for Biochemical Pharmacology by Subject "Inflammation"
Now showing items 1-20 of 22
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ACTH: The forgotten therapy
(2015-05) -
Dendritic cells and adipose tissue.
(2016-12)Visceral adipose tissue inflammation in obesity is an established risk factor for metabolic syndrome, which can include insulin resistance, type 2 diabetes, hypertension and cardiovascular diseases. With obesity and related ... -
Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections?
(2017-12)Infections arise when the host response is overwhelmed by pathogens leading to organ dysfunction. In some instances patients progress to more severe conditions, including septic shock, that are associated with increased ... -
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction.
(2019-08)BACKGROUND: Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators ... -
The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function.
(2018)Phosphoinositide-3 kinases (PI3Ks) generate 3-phosphorylated phosphoinositide lipids that are implicated in many biological processes in homeostatic states and pathologies such as cancer, inflammation and autoimmunity. ... -
Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes.
(Elsevier, 2019-11-11)Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize ... -
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.
(2021-02-02)Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue injury and as such have been proposed as therapeutic targets to promote inflammation resolution during sterile wound healing, including ... -
Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.
(2018-03-22)While the treatment of inflammatory disorders is generally based on inhibiting factors that drive onset of inflammation, these therapies can compromise healing (NSAIDs) or dampen immunity against infections (biologics). ... -
Prolonged immune alteration following resolution of acute inflammation in humans.
(2017)Acute inflammation is an immediate response to infection and injury characterised by the influx of granulocytes followed by phagocytosing mononuclear phagocytes. Provided the antigen is cleared and the immune system of the ... -
Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.
(2016-08-24)Resolution of inflammation is a finely regulated process mediated by specialized proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)-derived resolvins and maresins. The immunomodulatory role of SPMs ... -
Smile-It's in your blood!
(2014-10-01)