Browsing Centre for Biochemical Pharmacology by Author "Zampetaki, A"
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Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency.
Trevelin, SC; Zampetaki, A; Sawyer, G; Ivetic, A; Brewer, AC; Smyth, LA; Marelli-Berg, F; Köchl, R; Lechler, RI; Shah, AM (2021-08-10)Nox2 is a ROS-generating enzyme, deficiency of which increases suppression by Tregs in vitro and in an in vivo model of cardiac remodelling. Since Tregs have emerged as a candidate therapy in autoimmunity and transplantation, ...