Browsing Centre for Biochemical Pharmacology by Author "Thorp, EB"

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    • Immunometabolic Mechanisms of Heart Failure with Preserved Ejection Fraction. 

      Schiattarella, GG; Alcaide, P; Condorelli, G; Gillette, TG; Heymans, S; Jones, EAV; Kallikourdis, M; Lichtman, A; Marelli-Berg, F; Shah, S (2022-03)
      Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, already accounting for at least half of all heart failure (HF). As most patients with HFpEF are obese with metabolic syndrome, ...

    • Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. 

      DeBerge, M; Glinton, K; Subramanian, M; Wilsbacher, LD; Rothlin, CV; Tabas, I; Thorp, EB (2021-02-02)
      Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue injury and as such have been proposed as therapeutic targets to promote inflammation resolution during sterile wound healing, including ...