Browsing Centre for Biochemical Pharmacology by Author "Thorp, E"
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An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.
Subramanian, M; Hayes, CD; Thome, JJ; Thorp, E; Matsushima, GK; Herz, J; Farber, DL; Liu, K; Lakshmana, M; Tabas, I (2014-03)The phagocytosis of apoptotic cells (ACs), or efferocytosis, by DCs is critical for self-tolerance and host defense. Although many efferocytosis-associated receptors have been described in vitro, the functionality of these ... -
Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling.
Subramanian, M; Thorp, E; Tabas, I (2015-01-16)RATIONALE: Granulocyte macrophage colony-stimulating factor (GM-CSF, Csf2) is a growth factor for myeloid-lineage cells that has been implicated in the pathogenesis of atherosclerosis and other chronic inflammatory diseases. ...